There are many highly abundant proteins (nM – uM) that can provide information on the physiological state of system if measured in real time. To accomplish this, biosensors that can achieve simple workflows, rapid response times, and multiplexed measurements are ideal compared to ultrasensitive techniques that require complex workflows with long analysis times. We propose to develop electrochemical impedance bioresistors (IBRs) based on bioinspired MOFs for simple and rapid quantification of proteins.
The IBR operates by measuring analyte binding to a chemiresistor channel using EIS. This mode of signal transduction has previously been demonstrated for bulk detection of proteins and small molecules, and showed quantitative, sensitive, and specific detection of analytes despite its remarkably simple design. The IBR is a promising, but underdeveloped, method of analytical detection for point-of-care applications due to the availability of relatively low cost potentiostats, ease of use, and simple fabrication and miniaturization.
The Ogata lab aims to design new IBRs based on bioinspired nanomaterials for detection of protein biomarkers.
Research Team: Ruben Castillo Barberi
Alumni Research Team: Advikaa Dosajh

02.
Research Areas

User-centered Design
Using user-centered design to increase translation and impact of bioanalytical technologies.

Bioinspired Nanomaterials
Strategically design and discover bioinspired nanomaterials for bioanalytical technologies.

Biosensors: Simple and Sensitive
Develop simple, rapid, and quantitative biosensors for point-of-care applications.

Diagnostics for Gynecological Diseases
Innovate a diagnostic pipeline for gynecological diseases.